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Efficacy

Evaluation Model

Evaluation Indicator

Soothing

Inhibition of hyaluronidase

Inhibition of hyaluronidase

CAP stimulated model in HaCaT cells

Calcium concentration,  expression of TRPV1

UVB stimulated inflammation model in HaCaT cells

Measurement of inflammatory factors (TNF-α, IL-6, etc.)

LPS stimulated inflammation model in HaCaT cells

Measurement of inflammatory factors (IL-6, IL-8, TNF-α, IL- 1β, etc.)

C48/80 stimulated P815 mast cell degranulation model

Quantity of degranulation

3D skin damage model

Measurement of inflammatory factors (IL-6, IL-8, TNF-α, IL-1α, etc.)